NGC 5291: Implications for the Formation of Dwarf Irregular Galaxies

The possible formation and evolution of dwarf irregular galaxies from material derived from perturbed evolved galaxies is addressed via an HI study of a likely example, the peculiar system NGC 5291. This system, located in the western outskirts of the cluster Abell 3574, contains the lenticular galaxy NGC 5291 which is in close proximity to a disturbed companion and is flanked by an extensive complex of numerous knots extending roughly 4\u27 north and 4\u27 south of the galaxy. In an initial optical and radio study, Longmore et al. (1979, MNRAS, 188, 285) showed that these knots have the spectra of vigorous star-forming regions, and suggested that some may in fact be young dwarf irregular galaxies. High resolution 21-cm line observations taken with the VLA are presented here and reveal that the H I distribution associated with this system encompasses not only the entire N-S complex of optical knots, but also forms an incomplete ring or tail that extends approximately 3\u27 to the west. The HI associated with NGC 5291 itself shows a high velocity range; the Seashell is not detected. The formation mechanism for this unusual system is unclear and two models-a large, low-luminosity ram-swept disk, and a ram-swept interaction-are discussed. The HI in the system contains numerous concentrations, mostly along the N-S arc of the star-forming complexes, which generally coincide with one or more optical knots; the larger HI features contain several X 109 M0 of gas. Each of the knots is compared to a set of criteria designed to determine if these objects are bound against their own internal kinetic energy and are tidally stable relative to the host galaxy. An analysis of the properties of the H I concentrations surrounding the optical star-forming complexes indicates that at least the largest of these is a bound system; it also possesses a stellar component. It is suggested that this object is a genuinely young dwarf irregular galaxy that has evolved from the material associated with the system and that this entire complex contains several proto- or young dwarf irregular galaxies in various stages of development. We are therefore witnessing the early evolution of a number of genuinely young galaxies. Given the evident importance of the NGC 5291 system as a \u27\u27nursery\u27\u27 for young galaxies, careful modeling is required if we are to understand this remarkable galaxy

Using Regular Tree Grammars to enhance Sentence Realisation

International audienceFeature-based regular tree grammars (FRTG) can be used to generate the derivation trees of a feature-based tree adjoining grammar (FTAG). We make use of this fact to specify and implement both an FTAG-based sentence realiser and a benchmark generator for this realiser. We argue furthermore that the FRTG encoding enables us to improve on other proposals based on a grammar of TAG derivation trees in several ways. It preserves the compositional semantics that can be encoded in feature-based TAGs; it increases efficiency and restricts overgeneration; and it provides a uniform resource for generation, benchmark construction, and parsing

Comparing the performance of two TAG-based surface realisers using controlled grammar traversal

International audienceWe present GENSEM, a tool for generating input semantic representations for two sentence generators based on the same reversible Tree Adjoining Grammar. We then show how GENSEM can be used to produced large and controlled benchmarks and test the relative performance of these generators

Recursive quantum repeater networks

Internet-scale quantum repeater networks will be heterogeneous in physical technology, repeater functionality, and management. The classical control necessary to use the network will therefore face similar issues as Internet data transmission. Many scalability and management problems that arose during the development of the Internet might have been solved in a more uniform fashion, improving flexibility and reducing redundant engineering effort. Quantum repeater network development is currently at the stage where we risk similar duplication when separate systems are combined. We propose a unifying framework that can be used with all existing repeater designs. We introduce the notion of a Quantum Recursive Network Architecture, developed from the emerging classical concept of 'recursive networks', extending recursive mechanisms from a focus on data forwarding to a more general distributed computing request framework. Recursion abstracts independent transit networks as single relay nodes, unifies software layering, and virtualizes the addresses of resources to improve information hiding and resource management. Our architecture is useful for building arbitrary distributed states, including fundamental distributed states such as Bell pairs and GHZ, W, and cluster states.Comment: 14 page

ARP2/3- and resection-coupled genome reorganization facilitates translocations [preprint]

DNA end-resection and nuclear actin-based movements orchestrate clustering of double-strand breaks (DSBs) into homology-directed repair (HDR) domains. Here, we analyze how actin nucleation by ARP2/3 affects damage-dependent and -independent 3D genome reorganization and facilitates pathologic repair. We observe that DNA damage, followed by ARP2/3-dependent establishment of repair domains enhances local chromatin insulation at a set of damage-proximal boundaries and affects compartment organization genome-wide. Nuclear actin polymerization also promotes interactions between DSBs, which in turn facilitates aberrant intra- and inter-chromosomal rearrangements. Notably, BRCA1 deficiency, which decreases end-resection, DSB mobility, and subsequent HDR, nearly abrogates recurrent translocations between AsiSI DSBs. In contrast, loss of functional BRCA1 yields unique translocations genome-wide, reflecting a critical role in preventing spontaneous genome instability and subsequent rearrangements. Our work establishes that the assembly of DSB repair domains is coordinated with multiscale alterations in genome architecture that enable HDR despite increased risk of translocations with pathologic potential

The population of planetary nebulae and HII regions in M81. A study of radial metallicity gradients and chemical evolution

We analyze the chemical abundances of planetary nebulae and HII regions in the M81 disk for insight on galactic evolution, and compare it with that of other galaxies, including the Milky Way. We acquired Hectospec/MMT spectra of 39 PNe and 20 HII regions, with 33 spectra viable for temperature and abundance analysis. Our PN observations represent the first PN spectra in M81 ever published, while several HII region spectra have been published before, although without a direct electron temperature determination. We determine elemental abundances of helium, nitrogen, oxygen, neon, sulfur, and argon in PNe and HII regions, and determine their averages and radial gradients. The average O/H ratio of PNe compared to that of the HII regions indicates a general oxygen enrichment in M81 in the last ~10 Gyr. The PN metallicity gradient in the disk of M81 is -0.055+-0.02 dex/kpc. Neon and sulfur in PNe have a radial distribution similar to that of oxygen, with similar gradient slopes. If we combine our HII sample with the one in the literature we find a possible mild evolution of the gradient slope, with results consistent with gradient steepening with time. Additional spectroscopy is needed to confirm this trend. There are no Type I PNe in our M81 sample, consistently with the observation of only the brightest bins of the PNLF, the galaxy metallicity, and the evolution of post-AGB shells. Both the young and the old populations of M81 disclose shallow but detectable negative radial metallicity gradient, which could be slightly steeper for the young population, thus not excluding a mild gradients steepening with the time since galaxy formation. During its evolution M81 has been producing oxygen; its total oxygen enrichment exceeds that of other nearby galaxies.Comment: A&A, in pres

Associations of NINJ2 sequence variants with incident ischemic stroke in the Cohorts for Heart and Aging in Genomic Epidemiology (CHARGE) consortium

Background<p></p> Stroke, the leading neurologic cause of death and disability, has a substantial genetic component. We previously conducted a genome-wide association study (GWAS) in four prospective studies from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and demonstrated that sequence variants near the NINJ2 gene are associated with incident ischemic stroke. Here, we sought to fine-map functional variants in the region and evaluate the contribution of rare variants to ischemic stroke risk.<p></p> Methods and Results<p></p> We sequenced 196 kb around NINJ2 on chromosome 12p13 among 3,986 European ancestry participants, including 475 ischemic stroke cases, from the Atherosclerosis Risk in Communities Study, Cardiovascular Health Study, and Framingham Heart Study. Meta-analyses of single-variant tests for 425 common variants (minor allele frequency [MAF] ≥ 1%) confirmed the original GWAS results and identified an independent intronic variant, rs34166160 (MAF = 0.012), most significantly associated with incident ischemic stroke (HR = 1.80, p = 0.0003). Aggregating 278 putatively-functional variants with MAF≤ 1% using count statistics, we observed a nominally statistically significant association, with the burden of rare NINJ2 variants contributing to decreased ischemic stroke incidence (HR = 0.81; p = 0.026).<p></p> Conclusion<p></p> Common and rare variants in the NINJ2 region were nominally associated with incident ischemic stroke among a subset of CHARGE participants. Allelic heterogeneity at this locus, caused by multiple rare, low frequency, and common variants with disparate effects on risk, may explain the difficulties in replicating the original GWAS results. Additional studies that take into account the complex allelic architecture at this locus are needed to confirm these findings